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Molecule kills elderly cells, reduces signs of aging in miceby Prabhav Jain
Even if you aren’t elderly, your body is home to agents of senility—frail and damaged cells that age us and promote disease. Now, researchers have developed a molecule that selectively destroys these so-called senescent cells. The compound makes old mice act and appear more youthful, providing hope that it may do the same for us.
“It’s definitely a landmark advance in the field,” says cell and molecular biologist Francis Rodier of the University of Montreal in Canada who wasn’t connected to the study. “This is the first time that somebody has shown that you can get rid of senescent cells without having any obvious side effects.”
I didn't realize that there are already several clinical trials in the works in patients with kidney disease to test the effects of senolytics. The biggest drawback seems to be that "senescent...
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Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.by Alex K. Chen
Changes in Cognitive Function in Human Agingby Alex K. Chen
Good high-level overview I would send to someone new in the field
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Sex Differences in Lifespanby Alex K. Chen
Sex differences in longevity can provide insights into novel mechanisms of aging, yet they have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild animals. Evolutionary hypotheses accounting for longevity patterns in natural populations include differential vulnerability to environmental hazards, differential intensity of sexual selection, and distinct patterns of parental care. Mechanistic hypotheses focus on hormones, asymmetric inheritance of sex chromosomes and mitochondria. Virtually all intensively studied species show conditional sex differences in longevity. Humans are the only species in which one sex is known to have a ubiquitous survival advantage. Paradoxically, although women live longer, they suffer greater morbidity particularly late in life. This mortality-morbidity paradox may be a consequence of greater connective tissue responsiveness to sex hormones in women. Human females' longevity advantage may result from hormonal influences on inflammatory and immunological responses, or greater resistance to oxidative damage; current support for these mechanisms is weak.
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Why can’t humans regenerate body parts? We’ve got the genesby Anant Jain
"I believe humans have these same genes, and if we can figure out how to turn on these genes, we can regenerate."
What do you think of human body part regeneration in context of increasing lifespans? Has anyone come across published research on this?
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Investigating Differences in Brain Aging in Older Adultsby Alex K. Chen
Some loss of memory is often considered an inevitable part of aging, but new research reveals how some people appear to escape that fate. A study by Massachusetts General Hospital (MGH) investigators examines a remarkable group of older adults whose memory performance is equivalent to that of younger individuals and finds that certain key areas of their brains resemble those of young people.