Even if you aren’t elderly, your body is home to agents of senility—frail and damaged cells that age us and promote disease. Now, researchers have developed a molecule that selectively destroys these so-called senescent cells. The compound makes old mice act and appear more youthful, providing hope that it may do the same for us.
“It’s definitely a landmark advance in the field,” says cell and molecular biologist Francis Rodier of the University of Montreal in Canada who wasn’t connected to the study. “This is the first time that somebody has shown that you can get rid of senescent cells without having any obvious side effects.”
I didn't realize that there are already several clinical trials in the works in patients with kidney disease to test the effects of senolytics. The biggest drawback seems to be that "senescent cells also foster wound healing, and destroying the cells could impair this ability"... Killing off large numbers of senescent cells could still trigger a potentially fatal complication sometimes suffered by cancer patients."